Cabergoline is a synthetic ergoline derivative and a long-acting dopamine receptor agonist with high affinity for the dopamine D2 receptor. Cabergoline exerts an inhibitory effect on prolactin secretion by acting on dopamine receptors present in pituitary lactotrophs. This drug also binds to dopamine D2 receptors in the corpus striatum, thereby mimicking the actions of dopamine on motor control. Cabergoline also possesses antioxidant and neuroprotective properties due to its free radical scavenging activity. Cabergoline is used in the treatment of Parkinson’s disease and in the treatment of hyperprolactinemia.
Cabergoline, sold under the brand name Dostinex among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson’s disease, and for other indications. It is taken by mouth.
Cabergoline is an ergot derivative and a potent dopamine D2 receptor agonist.
Cabergoline was patented in 1980 and approved for medical use in 1993.
Cabergoline in bodybuilding settings is a popular medication that is known to greatly help mitigate some specific side effects of anabolic steroids. That’s why Cabergoline in bodybuilding is used as an ancillary medication for steroids to help users lower the side effects.
Cabergoline is most commonly sold as brand Dostinex. But can be found as numerous other brands such as Caber, Cabaser, and numerous others. It is a drug that was discovered by accident back in the 1980s when scientists were experimenting with ergot alkaloids. Therefore, this is an ergot derived drug (fungi derived).
This is an orally active compound (coming as pills) which is known as a dopamine agonist known for reducing serum prolactin levels. In medicine, Cabergoline is prescribed to people to find off hyperprolactinemia – the condition of too high prolactin levels that are produced by the pituitary gland. So, it is used for all needs when high prolactin levels are the main problem.
With this being said, Cabergoline in bodybuilding is used by those athletes that are running specific anabolic steroids.
Those that are capable of increasing prolactin levels to an excess. Usually, such steroids include Trenbolone and Nandrolone compounds.
How Cabergoline Works
As mentioned, Cabergoline is used in those situations when prolactin levels should be reduced. So, it is given to patients suffering from tumors and cancers related to high prolactin levels. Can be given to hyperprolactinemia, Parkinson’s disease, Cushing’s disease, and other purposes.
The medication is a long lasting dopamine D2 receptor agonist. According to studies done, Cabergoline is inhibiting the release of prolactin in the pituitary gland of lactotroph cells. Because prolactin isn’t secreted from the pituitary gland – serum prolactin levels are reduced.
Prolactin is that hormone that is allowing female mammals to produce milk. Is also that hormone that is making a man lose interest in sex after ejaculation. This is because prolactin levels spike in both cases.
Cabergoline Bodybuilding Uses
In bodybuilding settings, Cabergoline is actually having various uses. The most popular and widely used one is to add it during the use of Trenbolone or Nandrolone – the compounds that are known to offer the side effect of low sex drive (due to high prolactin levels).
So, Cabergoline in performance settings is mostly known to offer positive effects of sexual nature. When steroids like Nandrolone are offering the side effect of “Deca Dick” – erectile dysfunction or Trenbolone lowers sex drive – Cabergoline is often seen as the perfect solution.
But another use of Cabergoline in bodybuilding is to cause an adrenaline rush during an athletic event allowing individuals to “ignore” more pain and push muscles to the limits.
Other than that, Cabergoline has been linked with weight loss because using it, offers increased levels of dopamine allowing individuals to reduce their cravings for junk foods.
And lastly, Cabergoline has been associated with better sleep. Users may get more restful sleep allowing them to train longer and harder as well as to recover faster and better.
Cabergoline Side Effects
The most reported side effects of Cabergoline are associated with high dosages. They are related to stomach issues.
In order to avoid stomach issues, use the compound in proper dosages and with a meal. Also, is recommended to use it before going to bed.
Other side effects of Cabergoline are associated with too high prolactin suppression. And then again, too high dosages. Some possible Cabergoline side effects except for stomach issues that can be managed include:
- Hot flashes
Cabergoline Bodybuilding Administration
If Cabergoline is prescribed we highly recommend you to use it exactly as said by the doctor.
But if using it for the purpose of bodybuilding (lowering side effects of high prolactin levels caused by use of steroids) then the dosage is dependent on each individual’s responses as well as dosage and cycle length of steroids.
- In case you don’t have Trenbolone or Nandrolone in your cycle, you may not need Cabergoline at all.
But if you have both compounds used in higher doses for longer cycles, you may need Cabergoline. You may need more than another person running only one of these 2 compounds in lower doses in shorter cycles.
Dosages are falling in the range of 0.25 mg up to 1 mg twice per week (from 0.5 mg up to 2 mg per week). It has a long half life so using it twice weekly is enough (every 3-4 days).
- Is recommended to start at a low dosage of 0.25 mg per dose (0.5 mg weekly) as it may be enough for many.
- 0.5 mg per dose (1 mg weekly) is what most people find to be the perfect dosage.
- For most people, 1 mg (2 mg weekly) is too much – only a few people may need such a high dosage.
As mentioned, it is recommended to use it with food before going to bed.
Are there any alternatives?
There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.